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Title:

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Besch, R; Poeck, H; Hohenauer, T; Senft, D; Häcker, G; Berking, C; Hornung, V; Endres, S; Ruzicka, T; Rothenfusser, S; Hartmann, G
Abstract:
The retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated antigen 5 (MDA-5) helicases sense viral RNA in infected cells and initiate antiviral responses such as the production of type I IFNs. Here we have shown that RIG-I and MDA-5 also initiate a proapoptotic signaling pathway that is independent of type I IFNs. In human melanoma cells, this signaling pathway required the mitochondrial adapter Cardif (also known as IPS-1) and induced the proapoptotic BH3-only proteins P...     »
Journal title abbreviation:
J Clin Invest
Year:
2009
Journal volume:
119
Journal issue:
8
Pages contribution:
2399-411
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI37155
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19620789
Print-ISSN:
0021-9738
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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