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- Title:
Increased formation of sister chromatid exchanges, but not of micronuclei, in anaesthetists exposed to low levels of sevoflurane.
- Document type:
- Journal Article
- Author(s):
- Wiesner, G; Schiewe-Langgartner, F; Lindner, R; Gruber, M
- Abstract:
- We have assessed, for the first time, genotoxicity (i.e. sister chromatid exchanges and micronuclei) in anaesthetists exposed to a single volatile anaesthetic (sevoflurane) without nitrous oxide. The anaesthetists were exposed to an 8-h time-weighted average of 0.2 parts per million sevoflurane. Internists served as non-exposed controls. Mean (SD) sister chromatid exchanges per cell were significantly higher in anaesthetists compared to internists (6.6 (0.9) vs 5.1 (0.8); p < 0.001) whereas median (IQR [range]) micronuclei per 1000 binucleated cells did not differ (9.5 (6.3-10.8 [2.0-15.5]) vs 8.5 (6.0-10.5 [3.0-25.5]), respectively). Although the anaesthetists were exposed to rather low concentrations of sevoflurane, this 30% increase of sister chromatid exchanges is in agreement with a recently reported 300% increase with a high level exposure to sevoflurane and nitrous oxide. Omitting nitrous oxide does not normalise increased rates of sister chromatid exchanges.
- Journal title abbreviation:
- Anaesthesia
- Year:
- 2008
- Journal volume:
- 63
- Journal issue:
- 8
- Pages contribution:
- 861-4
- Language:
- eng
- Fulltext / DOI:
- doi:10.1111/j.1365-2044.2008.05498.x
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/18540930
- Print-ISSN:
- 0003-2409
- TUM Institution:
- Klinik für Anästhesiologie
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