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Title:

The role of epoxide hydrolase Y113H gene variant in pancreatic diseases.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Ockenga, J; Strunck, S; Post, C; Schulz, HU; Halangk, J; Pfützer, RH; Löhr, M; Oettle, H; Kage, A; Rosendahl, J; Keim, V; Drenth, JP; Jansen, JB; Lochs, H; Witt, H
Abstract:
OBJECTIVES: Chronic pancreatitis (CP) and pancreatic adenocarcinoma (pCA) are associated with risk factors such as alcohol intake and tobacco smoking. Microsomal epoxide hydrolase (EPHX1) is a phase II detoxifying enzyme capable of tobacco-borne toxicant inactivation. We studied the role of the EPHX1 c.337T>C (p.Y113H) variant, whichleads to altered enzyme activity, in pancreatic diseases. METHODS: We genotyped 2391 patients by melting curve analysis. We enrolled 367 patients with pCA, 341 patie...     »
Journal title abbreviation:
Pancreas
Year:
2009
Journal volume:
38
Journal issue:
4
Pages contribution:
e97-e101
Language:
eng
Fulltext / DOI:
doi:10.1097/MPA.0b013e31819feeed
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19287329
Print-ISSN:
0885-3177
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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