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Title:

Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signalling.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schröfelbauer, B; Raffetseder, J; Hauner, M; Wolkerstorfer, A; Ernst, W; Szolar, OH
Abstract:
The triterpene glycoside glycyrrhizin is the main active compound in liquorice. It is used as a herbal medicine owing to its anticancer, antiviral and anti-inflammatory properties. Its mode of action, however, remains widely unknown. In the present study, we aimed to elucidate the molecular mechanism of glycyrrhizin in attenuating inflammatory responses in macrophages. Using microarray analysis, we found that glycyrrhizin caused a broad block in the induction of pro-inflammatory mediators induce...     »
Journal title abbreviation:
Biochem J
Year:
2009
Journal volume:
421
Journal issue:
3
Pages contribution:
473-82
Language:
eng
Fulltext / DOI:
doi:10.1042/BJ20082416
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19442240
Print-ISSN:
0264-6021
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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