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Title:

Functional analyses reveal the greater potency of preadipocytes compared with adipocytes as endothelial cell activator under normoxia, hypoxia, and TNFalpha exposure.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Mack, I; BelAiba, RS; Djordjevic, T; Gorlach, A; Hauner, H; Bader, BL
Abstract:
Obesity is associated with a state of chronic low-grade inflammation. Immune cells accumulate in white adipose tissue (WAT). The vascular endothelium plays an interactive role in these infiltration and inflammatory processes. Mature and hypertrophic adipocytes are considered as the major adipogenic cell type secreting proinflammatory cytokines in WAT. In contrast, the proinflammatory capacity of preadipocytes and their role in endothelial cell activation have been neglected so far. To gain new i...     »
Journal title abbreviation:
Am J Physiol Endocrinol Metab
Year:
2009
Journal volume:
297
Journal issue:
3
Pages contribution:
E735-48
Language:
eng
Fulltext / DOI:
doi:10.1152/ajpendo.90851.2008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19549791
Print-ISSN:
0193-1849
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin; Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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