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Titel:

Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Laumen, H; Saningong, AD; Heid, IM; Hess, J; Herder, C; Claussnitzer, M; Baumert, J; Lamina, C; Rathmann, W; Sedlmeier, EM; Klopp, N; Thorand, B; Wichmann, HE; Illig, T; Hauner, H
Abstract:
OBJECTIVE: Adiponectin (APM1, ACDC) is an adipocyte-derived protein with downregulated expression in obesity and insulin-resistant states. Several potentially regulatory single nucleotide polymorphisms (SNPs) within the APM1 gene promoter region have been associated with circulating adiponectin levels. None of them have been functionally characterized in adiponectin-expressing cells. Hence, we investigated three SNPs (rs16861194, rs17300539, and rs266729) for their influence on adiponectin promo...     »
Zeitschriftentitel:
Diabetes
Jahr:
2009
Band / Volume:
58
Heft / Issue:
4
Seitenangaben Beitrag:
984-91
Sprache:
eng
Volltext / DOI:
doi:10.2337/db07-1646
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19074982
Print-ISSN:
0012-1797
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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