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Title:

A disintegrin and metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schelter, F; Kobuch, J; Moss, ML; Becherer, JD; Comoglio, PM; Boccaccio, C; Kruger, A
Abstract:
Met, the tyrosine kinase receptor for the hepatocyte growth factor is a prominent regulator of cancer cell invasiveness and has emerged as a promising therapeutic target. Binding of the anti-Met monoclonal antibody DN30 to its epitope induces the proteolytic cleavage of Met, thereby impairing the invasive growth of tumors. The molecular mechanism controlling this therapeutic shedding process has so far been unknown. Here, we report that A Disintegrin And Metalloproteinase (ADAM)-10, but not ADAM...     »
Journal title abbreviation:
J Biol Chem
Year:
2010
Journal volume:
285
Journal issue:
34
Pages contribution:
26335-40
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.M110.106435
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20554517
Print-ISSN:
0021-9258
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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