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Title:

Gene silencing mediated by magnetic lipospheres tagged with small interfering RNA.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
del Pino, P; Munoz-Javier, A; Vlaskou, D; Rivera Gil, P; Plank, C; Parak, WJ
Abstract:
Lipospheres made from soy bean oil and a combination of the cationic lipid Metafectene and the helper lipid dioleoylphosphatidyl-ethanolamine were functionalized with magnetic nanoparticles (NPs) and small interfering RNA (siRNA). The resulting magnetic lipospheres loaded with siRNA are proven here as efficient nonviral vectors for gene silencing. Embedding magnetic NPs in the shell of lipospheres allows for magnetic force-assisted transfection (magnetofection) as well as magnetic targeting in b...     »
Journal title abbreviation:
Nano Lett
Year:
2010
Journal volume:
10
Journal issue:
10
Pages contribution:
3914-21
Language:
eng
Fulltext / DOI:
doi:10.1021/nl102485v
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20836536
Print-ISSN:
1530-6984
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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