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Titel:

Boosting oncolytic adenovirus potency with magnetic nanoparticles and magnetic force.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Tresilwised, N; Pithayanukul, P; Mykhaylyk, O; Holm, PS; Holzmüller, R; Anton, M; Thalhammer, S; Adigüzel, D; Doblinger, M; Plank, C
Abstract:
Oncolytic adenoviruses rank among the most promising innovative agents in cancer therapy. We examined the potential of boosting the efficacy of the oncolytic adenovirus dl520 by associating it with magnetic nanoparticles and magnetic-field-guided infection in multidrug-resistant (MDR) cancer cells in vitro and upon intratumoral injection in vivo. The virus was complexed by self-assembly with core-shell nanoparticles having a magnetite core of about 10 nm and stabilized by a shell containing 68 m...     »
Zeitschriftentitel:
Mol Pharm
Jahr:
2010
Band / Volume:
7
Heft / Issue:
4
Seitenangaben Beitrag:
1069-89
Sprache:
eng
Volltext / DOI:
doi:10.1021/mp100123t
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20550160
Print-ISSN:
1543-8384
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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