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Titel:

Gene silencing mediated by magnetic lipospheres tagged with small interfering RNA.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
del Pino, P; Munoz-Javier, A; Vlaskou, D; Rivera Gil, P; Plank, C; Parak, WJ
Abstract:
Lipospheres made from soy bean oil and a combination of the cationic lipid Metafectene and the helper lipid dioleoylphosphatidyl-ethanolamine were functionalized with magnetic nanoparticles (NPs) and small interfering RNA (siRNA). The resulting magnetic lipospheres loaded with siRNA are proven here as efficient nonviral vectors for gene silencing. Embedding magnetic NPs in the shell of lipospheres allows for magnetic force-assisted transfection (magnetofection) as well as magnetic targeting in b...     »
Zeitschriftentitel:
Nano Lett
Jahr:
2010
Band / Volume:
10
Heft / Issue:
10
Seitenangaben Beitrag:
3914-21
Sprache:
eng
Volltext / DOI:
doi:10.1021/nl102485v
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20836536
Print-ISSN:
1530-6984
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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