Gliobastomas are characterized by invasion in surrounding brain tissue and radioresistance. In the present paper, we examined cell survival, invasion and integrin/matrix metalloproteinase-2 and -9 interactions in human glioblastoma cell lines. Cellular radioresistance was enhanced by adhesion to extracellular matrix dependent on the cell line, whereas radiogenic induction of β1- and β3-integrins correlates with increased adhesion. Irradiation reduced invasion in a cell line-dependent manner. Mechanistically, a regulatory influence of β1- and β3-integrins especially on matrix-metalloproteinase-2 was demonstrated. Conclusively, β1- and β3-integrins play an essential role for the radiosensitivity and invasion of human glioblastoma cells.
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Gliobastomas are characterized by invasion in surrounding brain tissue and radioresistance. In the present paper, we examined cell survival, invasion and integrin/matrix metalloproteinase-2 and -9 interactions in human glioblastoma cell lines. Cellular radioresistance was enhanced by adhesion to extracellular matrix dependent on the cell line, whereas radiogenic induction of β1- and β3-integrins correlates with increased adhesion. Irradiation reduced invasion in a cell line-dependent manner. Mec...
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