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Title:

Timing and targeting of cell-based VEGF165 gene expression in ischemic tissue.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Spanholtz, T; Maichle, A; Niedworok, C; Stoeckelhuber, BM; Krüger, S; Wedel, T; Aach, T; Middeler, G; Hellwig-Bürgel, T; Bader, A; Krengel, S; Müller, OJ; Franz, WM; Lindenmaier, W; Machens, HG
Abstract:
BACKGROUND: Therapeutic angiogenesis has become a key technology in experimental and clinical medicine. Only few data are available on the effects of timing and targeting of therapeutic proteins after cell-based gene transfer. This work investigates such effects after temporary expression of vascular endothelial growth factor 165 (VEGF(165)), the most commonly used angiogenic protein for therapeutic purposes. METHODS: We established a cell-based gene-transfer model using fibroblasts to temporari...     »
Journal title abbreviation:
J Surg Res
Year:
2009
Journal volume:
151
Journal issue:
1
Pages contribution:
153-62
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jss.2008.01.038
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18621399
Print-ISSN:
0022-4804
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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