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Title:

Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease.

Document type:
Journal Article; Article
Author(s):
Drzezga, A; Grimmer, T; Henriksen, G; Muhlau, M; Perneczky, R; Miederer, I; Praus, C; Sorg, C; Wohlschläger, A; Riemenschneider, M; Wester, HJ; Foerstl, H; Schwaiger, M; Kurz, A
Abstract:
OBJECTIVE: To examine the influence of the APOE genotype on levels of beta-amyloid (Abeta) plaque load and atrophy in patients with Alzheimer disease (AD) in vivo. METHODS: Thirty-two patients with moderate AD were divided into carriers and noncarriers of the epsilon4 allele. These groups were matched for age, disease duration, education, and cognitive impairment. In all subjects, [11C]PIB-PET was performed for measurement of cerebral Abeta plaque deposition and cranial MRI for the assessment of...     »
Journal title abbreviation:
Neurology
Year:
2009
Journal volume:
72
Journal issue:
17
Pages contribution:
1487-94
Language:
eng
Fulltext / DOI:
doi:10.1212/WNL.0b013e3181a2e8d0
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19339712
Print-ISSN:
0028-3878
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer); Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Psychiatrie und Psychotherapie; Neurologische Klinik und Poliklinik
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