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Title:

Restoration of contact inhibition in human glioblastoma cell lines after MIF knockdown.

Document type:
Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schrader, J; Deuster, O; Rinn, B; Schulz, M; Kautz, A; Dodel, R; Meyer, B; Al-Abed, Y; Balakrishnan, K; Reese, JP; Bacher, M
Abstract:
BACKGROUND: Studies of the role of the cytokine macrophage-migration-inhibitory-factor (MIF) in malignant tumors have revealed its stimulating influence on cell-cycle progression, angiogenesis and anti-apoptosis. RESULTS: Here we show that in vitro targeting MIF in cultures of human malignant glioblastoma cells by either antisense plasmid introduction or anti-MIF antibody treatment reduced the growth rates of tumor cells. Of note is the marked decrease of proliferation under confluent and over-c...     »
Journal title abbreviation:
BMC Cancer
Year:
2009
Journal volume:
9
Pages contribution:
464
Language:
eng
Fulltext / DOI:
doi:10.1186/1471-2407-9-464
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20038293
TUM Institution:
Neurochirurgische Klinik und Poliklinik
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