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Titel:

Effects of the PDE5-inhibitor vardenafil in a mouse stroke model.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Royl, G; Balkaya, M; Lehmann, S; Lehnardt, S; Stohlmann, K; Lindauer, U; Endres, M; Dirnagl, U; Meisel, A
Abstract:
Recent experimental studies in rodents suggest that treatment with inhibitors of phosphodiesterase type 5 (PDE5) (tadalafil, sildenafil, zaprinast) not only increases cerebral blood flow but also improves functional recovery after stroke. Here, we investigated in a mouse model of stroke the effects of vardenafil on survival, functional outcome and lesion size after experimental stroke. Mice were subjected to experimental stroke by occlusion of the middle cerebral artery (MCAO) for 45 min. A grou...     »
Zeitschriftentitel:
Brain Res
Jahr:
2009
Band / Volume:
1265
Seitenangaben Beitrag:
148-57
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.brainres.2009.01.061
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19368809
Print-ISSN:
0006-8993
TUM Einrichtung:
Neurochirurgische Klinik und Poliklinik
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