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Titel:

No effect of the PPAR-gamma agonist rosiglitazone on ACTH or cortisol secretion in Nelson's syndrome and Cushing's disease in vitro and in vivo.

Dokumenttyp:
Journal Article; Clinical Trial; In Vitro; Article
Autor(en):
Kreutzer, J; Jeske, I; Hofmann, B; Blümcke, I; Fahlbusch, R; Buchfelder, M; Buslei, R
Abstract:
OBJECTIVE: Surgical tumor resection remains the primary treatment strategy in ACTH-secreting pituitary adenomas, i.e. Cushing's disease (CD) and Nelson's syndrome (NS). However, an effective long-term pharmacological regime is not available in patients with persistent ACTH-hypersecretion. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma) is abundantly expressed in most pituitary adenomas. First encouraging data reported that the PPAR-gamma ligand rosiglitazone an...     »
Zeitschriftentitel:
Clin Neuropathol
Jahr:
2009
Band / Volume:
28
Heft / Issue:
6
Seitenangaben Beitrag:
430-9
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19919817
Print-ISSN:
0722-5091
TUM Einrichtung:
Neurochirurgische Klinik und Poliklinik
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