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Titel:

Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Intramural; Article
Autor(en):
Pechhold, K; Zhu, X; Harrison, VS; Lee, J; Chakrabarty, S; Koczwara, K; Gavrilova, O; Harlan, DM
Abstract:
OBJECTIVE: Insulin deficiency in type 1 diabetes and in rodent autoimmune diabetes models is caused by beta-cell-specific killing by autoreactive T-cells. Less is known about beta-cell numbers and phenotype remaining at diabetes onset and the fate of other pancreatic endocrine cellular constituents. RESEARCH DESIGN AND METHODS: We applied multicolor flow cytometry, confocal microscopy, and immunohistochemistry, supported by quantitative RT-PCR, to simultaneously track pancreatic endocrine cell f...     »
Zeitschriftentitel:
Diabetes
Jahr:
2009
Band / Volume:
58
Heft / Issue:
5
Seitenangaben Beitrag:
1175-84
Sprache:
eng
Volltext / DOI:
doi:10.2337/db08-0616
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19228810
Print-ISSN:
0012-1797
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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