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Title:

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.

Document type:
Journal Article; Review
Author(s):
Ebbesen, P; Pettersen, EO; Gorr, TA; Jobst, G; Williams, K; Kieninger, J; Wenger, RH; Pastorekova, S; Dubois, L; Lambin, P; Wouters, BG; Van Den Beucken, T; Supuran, CT; Poellinger, L; Ratcliffe, P; Kanopka, A; Gorlach, A; Gasmann, M; Harris, AL; Maxwell, P; Scozzafava, A
Abstract:
Cancer cells in hypoxic areas of solid tumors are to a large extent protected against the action of radiation as well as many chemotherapeutic drugs. There are, however, two different aspects of the problem caused by tumor hypoxia when cancer therapy is concerned: One is due to the chemical reactions that molecular oxygen enters into therapeutically targeted cells. This results in a direct chemical protection against therapy by the hypoxic microenvironment, which has little to do with cellular b...     »
Journal title abbreviation:
J Enzyme Inhib Med Chem
Year:
2009
Journal volume:
24 Suppl 1
Pages contribution:
1-39
Language:
eng
Fulltext / DOI:
doi:10.1080/14756360902784425
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19330638
Print-ISSN:
1475-6366
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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