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Title:

Targeting SGK1 in diabetes.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Author(s):
Lang, F; Gorlach, A; Vallon, V
Abstract:
Compelling evidence is accumulating indicating a pathophysiological role of the serum-and-glucocorticoid-inducible-kinase-1 (SGK1) in the development and complications of diabetes. SGK1 is ubiquitously expressed with exquisitely high transcriptional volatility. Stimulators of SGK1 expression include hyperglycemia, cell shrinkage, ischemia, glucocorticoids and mineralocorticoids. SGK1 is activated by insulin and growth factors via PI3K, 3-phosphoinositide dependent kinase PDK1 and mTOR. SGK1 acti...     »
Journal title abbreviation:
Expert Opin Ther Targets
Year:
2009
Journal volume:
13
Journal issue:
11
Pages contribution:
1303-11
Language:
eng
Fulltext / DOI:
doi:10.1517/14728220903260807
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19764891
Print-ISSN:
1472-8222
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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