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Titel:

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia.

Dokumenttyp:
Journal Article; Review
Autor(en):
Rzymski, T; Milani, M; Singleton, DC; Harris, AL
Abstract:
Tumor hypoxia confers resistance to many modalities of anticancer therapy. The endoplasmic reticulum (ER) is highly sensitive to severe hypoxic stress and results in the activation of the unfolded protein response. ATF4 is the main transcriptional regulator of the cellular hypoxic response to the Unfolded Protein Response (UPR) and activates genes that promote restoration of normal ER function and survival under hypoxia. Elevated expression of ATF4 is associated with resistance to current chemot...     »
Zeitschriftentitel:
Cell Cycle
Jahr:
2009
Band / Volume:
8
Heft / Issue:
23
Seitenangaben Beitrag:
3838-47
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19887912
Print-ISSN:
1538-4101
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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