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Titel:

Targeting SGK1 in diabetes.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Autor(en):
Lang, F; Gorlach, A; Vallon, V
Abstract:
Compelling evidence is accumulating indicating a pathophysiological role of the serum-and-glucocorticoid-inducible-kinase-1 (SGK1) in the development and complications of diabetes. SGK1 is ubiquitously expressed with exquisitely high transcriptional volatility. Stimulators of SGK1 expression include hyperglycemia, cell shrinkage, ischemia, glucocorticoids and mineralocorticoids. SGK1 is activated by insulin and growth factors via PI3K, 3-phosphoinositide dependent kinase PDK1 and mTOR. SGK1 acti...     »
Zeitschriftentitel:
Expert Opin Ther Targets
Jahr:
2009
Band / Volume:
13
Heft / Issue:
11
Seitenangaben Beitrag:
1303-11
Sprache:
eng
Volltext / DOI:
doi:10.1517/14728220903260807
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19764891
Print-ISSN:
1472-8222
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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