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Title:

Sequence independent interferon-alpha induction by multimerized phosphodiester DNA depends on spatial regulation of Toll-like receptor-9 activation in plasmacytoid dendritic cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Haas, T; Schmitz, F; Heit, A; Wagner, H
Abstract:
Single-stranded versus multimeric phosphorothioate-modified CpG oligodeoxynucleotides (ODNs) undergo differential endosomal trafficking upon uptake into plasmacytoid dendritic cells (pDCs), correlating with Toll-like receptor-9-dependent pDC maturation/activation (single-stranded B-type CpG ODN) or interferon-alpha (IFN-alpha) induction (multimeric A-type CpG ODN), respectively. As was recently shown, IFN-alpha production, other than by CpG ODNs, can also be induced in a sequence-independent man...     »
Journal title abbreviation:
Immunology
Year:
2009
Journal volume:
126
Journal issue:
2
Pages contribution:
290-8
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1365-2567.2008.02897.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19019086
Print-ISSN:
0019-2805
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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