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Title:

Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Renström, J; Istvanffy, R; Gauthier, K; Shimono, A; Mages, J; Jardon-Alvarez, A; Kröger, M; Schiemann, M; Busch, DH; Esposito, I; Lang, R; Peschel, C; Oostendorp, RA
Abstract:
Secreted frizzled-related protein 1 (Sfrp1) is highly expressed by stromal cells maintaining hematopoietic stem cells (HSCs). Sfrp1 loss in stromal cells increases production of hematopoietic progenitors, and in knockout mice, dysregulates hemostasis and increases Flk2- Cd34- Lin- Sca1+ Kit+ (LSK) cell numbers in bone marrow. Also, LSK and multipotent progenitors (MPPs) resided mainly in the G0/G1 phase of cell cycle, with an accompanying decrease in intracellular beta-catenin levels. Gene-expre...     »
Journal title abbreviation:
Cell Stem Cell
Year:
2009
Journal volume:
5
Journal issue:
2
Pages contribution:
157-67
Language:
eng
Fulltext / DOI:
doi:10.1016/j.stem.2009.05.020
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19664990
Print-ISSN:
1934-5909
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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