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Title:

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.

Document type:
journal article
Author(s):
Schlee, M; Roth, A; Hornung, V; Hagmann, CA; Wimmenauer, V; Barchet, W; Coch, C; Janke, M; Mihailovic, A; Wardle, G; Juranek, S; Kato, H; Kawai, T; Poeck, H; Fitzgerald, KA; Takeuchi, O; Akira, S; Tuschl, T; Latz, E; Ludwig, J; Hartmann, G
Abstract:
Antiviral immunity is triggered by immunorecognition of viral nucleic acids. The cytosolic helicase RIG-I is a key sensor of viral infections and is activated by RNA containing a triphosphate at the 5' end. The exact structure of RNA activating RIG-I remains controversial. Here, we established a chemical approach for 5' triphosphate oligoribonucleotide synthesis and found that synthetic single-stranded 5' triphosphate oligoribonucleotides were unable to bind and activate RIG-I. Conversely, the a...     »
Journal title abbreviation:
Immunity
Year:
2009
Journal volume:
31
Journal issue:
1
Pages contribution:
25-34
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19576794
Print-ISSN:
1074-7613
TUM Institution:
III. Medizinische Klinik und Poliklinik
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