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Title:

Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hauswald, S; Duque-Afonso, J; Wagner, MM; Schertl, FM; Lübbert, M; Peschel, C; Keller, U; Licht, T
Abstract:
PURPOSE: Histone deacetylase inhibitors (HDACi) are being studied in clinical trials with the aim to induce cellular differentiation, growth arrest, and apoptosis of tumor cells. Recent reports suggest that the multidrug resistance-1 (MDR1) gene is regulated by epigenetic mechanisms. To investigate whether additional drug transporters are regulated by HDACi and how this affects cytotoxicity, acute myeloid leukemia (AML) cells were examined. EXPERIMENTAL DESIGN: AML cells were cultured in the pre...     »
Journal title abbreviation:
Clin Cancer Res
Year:
2009
Journal volume:
15
Journal issue:
11
Pages contribution:
3705-15
Language:
eng
Fulltext / DOI:
doi:10.1158/1078-0432.CCR-08-2048
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19458058
Print-ISSN:
1078-0432
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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