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Title:

Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bourquin, C; Schmidt, L; Lanz, AL; Storch, B; Wurzenberger, C; Anz, D; Sandholzer, N; Mocikat, R; Berger, M; Poeck, H; Hartmann, G; Hornung, V; Endres, S
Abstract:
RNA oligonucleotides containing immune-activating sequences promote the development of cytotoxic T cell and B cell responses to Ag. In this study, we show for the first time that immunostimulatory RNA oligonucleotides induce a NK cell response that prevents growth of NK-sensitive tumors. Treatment of mice with immunostimulatory RNA oligonucleotides activates NK cells in a sequence-dependent manner, leading to enhanced IFN-gamma production and increased cytotoxicity. Use of gene-deficient mice sh...     »
Journal title abbreviation:
J Immunol
Year:
2009
Journal volume:
183
Journal issue:
10
Pages contribution:
6078-86
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.0901594
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19890064
Print-ISSN:
0022-1767
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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