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Titel:

Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ablasser, A; Poeck, H; Anz, D; Berger, M; Schlee, M; Kim, S; Bourquin, C; Goutagny, N; Jiang, Z; Fitzgerald, KA; Rothenfusser, S; Endres, S; Hartmann, G; Hornung, V
Abstract:
Detection of non-self RNA by TLRs within endosomes and by retinoic acid-inducible gene I (RIG-I)-like helicases in the cytosol is central to mammalian antiviral immunity. In this study, we used pathway-specific agonists and targeted delivery to address RNA immunorecognition in primary human immune cells. Within PBMC, plasmacytoid dendritic cells (pDC) and monocytes were found to be responsible for IFN-alpha production upon immunorecognition of RNA. The mechanisms of RNA recognition in pDC and mo...     »
Zeitschriftentitel:
J Immunol
Jahr:
2009
Band / Volume:
182
Heft / Issue:
11
Seitenangaben Beitrag:
6824-33
Sprache:
eng
Volltext / DOI:
doi:10.4049/jimmunol.0803001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19454678
Print-ISSN:
0022-1767
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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