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Dokumenttyp:
Journal Article
Autor(en):
Sproll, KC; Balló, H; Hoffmann, TK; Scheckenbach, K; Koldovsky, U; Balz, V; Hafner, D; Ramp, U; Bier, H
Titel:
Is there a role for the Fas-/Fas-Ligand pathway in chemoresistance of human squamous cell carcinomas of the head and neck (SCCHN)?
Abstract:
The aim of the present investigation was to determine the expression of the Fas-receptor/ligand system in established cell lines of squamous cell carcinomas of the head and neck (SCCHN), and to study it's functional impact on chemotherapy-induced apoptosis in these SCCHN cell lines. We observed constitutive expression of Fas and FasL in 13 SCCHN cell lines by RT-PCR, Southern-blotting and immunocytochemistry, respectively. Administration of the agonistic Fas-antibody CH-11 led to a significant r...     »
Zeitschriftentitel:
Oral Oncol
Jahr:
2009
Band / Volume:
45
Heft / Issue:
1
Seitenangaben Beitrag:
69-84
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.oraloncology.2008.04.003
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18620901
Print-ISSN:
1368-8375
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik
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