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Titel:

A novel mechanism for anti-EGFR antibody action involves chemokine-mediated leukocyte infiltration.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Hoffmann, TK; Schirlau, K; Sonkoly, E; Brandau, S; Lang, S; Pivarcsi, A; Balz, V; Müller, A; Homey, B; Boelke, E; Reichert, T; Friebe-Hoffmann, U; Greve, J; Schüler, P; Scheckenbach, K; Schipper, J; Bas, M; Whiteside, TL; Bier, H
Abstract:
Overexpression of the epidermal growth factor receptor (EGFR) is a hallmark of squamous cell carcinoma of the head and neck (SCCHN). Monoclonal antibodies (mAbs) against EGFR are currently used for therapy of recurrent or metastatic disease; however, their mode of action is not completely understood. To investigate the immunological effects of anti-EGFR mAb, we generated a three-dimensional spheroid model of EGFR-expressing SCCHN and used this model to study the effect of anti-EGFR mAb on leuko...     »
Zeitschriftentitel:
Int J Cancer
Jahr:
2009
Band / Volume:
124
Heft / Issue:
11
Seitenangaben Beitrag:
2589-96
Sprache:
eng
Volltext / DOI:
doi:10.1002/ijc.24269
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19208382
Print-ISSN:
0020-7136
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik
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