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Title:

Memory B cell function in HIV-infected children-decreased memory B cells despite ART.

Document type:
Journal Article
Author(s):
Ghosh, S; Feyen, O; Jebran, AF; Huck, K; Jetzek-Zader, M; Bas, M; Niehues, T
Abstract:
B cell dysfunction is a well-studied complication of HIV infection in adults. Data on B cell differentiation in normal and HIV-infected children are lacking. We show the distribution of B cell subsets and immunoglobulin levels in HIV-infected children compared with controls. Furthermore, we observe the long-term B cell reconstitution of vaccine-specific immunity after antiretroviral therapy (ART). Phenotype of B cells (naive, non-switched memory, switched memory) was analyzed in 48 infected chil...     »
Journal title abbreviation:
Pediatr Res
Year:
2009
Journal volume:
66
Journal issue:
2
Pages contribution:
185-90
Language:
eng
Fulltext / DOI:
doi:10.1203/PDR.0b013e3181aa057d
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19390488
Print-ISSN:
0031-3998
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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