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Title:

Optimization of platelet isolation and extraction of autogenous TGF-beta in cartilage tissue engineering.

Document type:
Journal Article
Author(s):
Staudenmaier, R; Froelich, K; Birner, M; Kindermann, J; The Hoang, N; Pueschel, RC; Mandlik, V
Abstract:
Platelets are enriched with Transforming Growth Factor-beta (TGF-beta). However, information is limited concerning TGF-beta's effects at the molecular level. Nevertheless, it has been demonstrated that TGF-beta activates cell proliferation and its positive influence on cartilage formation has been proven within the field of Tissue Engineering (TE). As Platelet Rich Plasma (PRP) contains TGF-beta, it was the purpose of this study to optimize PRP-isolation for further TGF-beta extraction. Red bloo...     »
Journal title abbreviation:
Artif Cells Blood Substit Immobil Biotechnol
Year:
2009
Journal volume:
37
Journal issue:
6
Pages contribution:
265-72
Language:
eng
Fulltext / DOI:
doi:10.3109/10731190903356446
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19922166
Print-ISSN:
1073-1199
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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