Anti-MICA antibodies are related to adverse outcome in heart transplant recipients.

Kauke, T; Kaczmarek, I; Dick, A; Schmoeckel, M; Deutsch, MA; Beiras-Fernandez, A; Reichart, B; Spannagl, M

doi:10.1016/j.healun.2009.01.003

2009

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Title:: Anti-MICA antibodies are related to adverse outcome in heart transplant recipients.
Document type:: Journal Article; Article
Author(s):: Kauke, T; Kaczmarek, I; Dick, A; Schmoeckel, M; Deutsch, MA; Beiras-Fernandez, A; Reichart, B; Spannagl, M
Abstract:: The clinical relevance of the post-transplant presence of anti-major histocompatibility complex class I chain-related A (MICA) antibodies as a marker for chronic graft failure in heart transplantation was examined using post-transplant sera from 159 heart transplant recipients. Mean follow-up after transplantation was 7 +/- 4.9 years.The sera were screened by Luminex (Luminex Corp, Austin, TX) for MICA antibodies. Samples that tested positive were confirmed using a Luminex MICA single-antigen bead assay. The antigen specificity of the detected antibodies was identified. Outcome parameters were survival, cardiac allograft vasculopathy (CAV), and cellular rejection.We retrospectively selected 159 patients: 107 with 0 or 1 rejection and 52 with 2 or more acute rejection episodes, of whom 36 (22.6%) had a positive screen for anti-MICA antibodies. In 19 of 36 samples, specific anti-MICA antibodies were confirmed by single antigen assay. The presence of post-transplant specified anti-MICA antibodies in patients' sera was associated with acute rejection (63.2% vs 28.6%, p < 0.01) and CAV (78.9% vs 32.8%, p < 0.01). Multivariate analysis identified anti-MICA positivity as an independent risk factor for the development of CAV.The results indicate that anti-MICA antibodies may be related to adverse outcome after heart transplantation. Post-transplantation monitoring of anti-MICA antibodies could identify patients with an increased risk for acute rejection and vasculopathy.
Journal title abbreviation:: J Heart Lung Transplant
Year:: 2009
Journal volume:: 28
Journal issue:: 4
Pages contribution:: 305-11
Language:: eng
Fulltext / DOI:: doi:10.1016/j.healun.2009.01.003
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/19332255
Print-ISSN:: 1053-2498
TUM Institution:: Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Gefäßchirurgie (DHM) (Prof. Krane)2009