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Title:

Functional genetic mouse models: promising tools for investigation of the proteolytic internet.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Kruger, A
Abstract:
Knockout mice are the gold standard to probe for the role of a specific protease within the interacting network of proteases, substrates, and inhibitors. This proteolytic network, or protease web, determines cell signaling and organ homeostasis. Therefore, protease deficiency or inhibition is intrinsically tied to alterations within this network, always leading to new molecular phenotypes, which define susceptibility of an organ to disease. Furthermore, recent hints, mainly from research on matr...     »
Journal title abbreviation:
Biol Chem
Year:
2009
Journal volume:
390
Journal issue:
2
Pages contribution:
91-7
Language:
eng
Fulltext / DOI:
doi:10.1515/BC.2009.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19040350
Print-ISSN:
1431-6730
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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