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Title:

Subcutaneous administration of epidermal growth factor: a true treatment option in case of postoperative liver failure?

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Glanemann, M; Shi, B; El-Zidy, N; Gaebelein, G; Kronbach, Z; Neuhaus, P; Nüssler, AK
Abstract:
Adequate hepatocyte regeneration is mandatory for successful recovery after liver resection. The role of epidermal growth factor (EGF), by subcutaneous injection as a simple route, has not been clearly elucidated yet. Wistar rats underwent 70 or 90% hepatectomy, respectively, and were treated with EGF at day 2 and 3 or served as non-EGF-treated controls. Postoperatively, proliferative parameters (weight of liver remnants, number of mitotic and Ki-67 positive cells, expression of cyclin D1 protei...     »
Journal title abbreviation:
Int J Surg
Year:
2009
Journal volume:
7
Journal issue:
3
Pages contribution:
200-5
Fulltext / DOI:
doi:10.1016/j.ijsu.2009.03.004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19332157
Print-ISSN:
1743-9191
TUM Institution:
Klinik und Poliklinik für Unfallchirurgie
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