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Titel:

Solid tumours arising from differently pre-oxygenated cells: comparable growth rates despite dissimilar tissue oxygenation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Mayer, A; Steimel, M; Wree, A; Kelleher, D; Vaupel, P
Abstract:
PURPOSE: The hypoxia-inducible factor (HIF)-dependent transcriptional response is often very pronounced in hypoxic microregions of solid malignant tumours, leading to secretion of pro-angiogenic factors and activation of a hypoxia-tolerant, glycolytic metabolism. Here, the influence of the microenvironment of tumour-initiating cells as a factor determining intertumoural variations in the relative contributions of both processes has been examined. MATERIAL AND METHODS: The oxygenation status was...     »
Zeitschriftentitel:
Int J Radiat Biol
Jahr:
2009
Band / Volume:
85
Heft / Issue:
11
Seitenangaben Beitrag:
981-8
Sprache:
eng
Volltext / DOI:
doi:10.3109/09553000903232843
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19895275
Print-ISSN:
0955-3002
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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