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Title:

The influence of x-ray contrast agents in computed tomography on the induction of dicentrics and gamma-H2AX foci in lymphocytes of human blood samples.

Document type:
Journal Article; Article
Author(s):
Jost, G; Golfier, S; Pietsch, H; Lengsfeld, P; Voth, M; Schmid, TE; Eckardt-Schupp, F; Schmid, E
Abstract:
The aim of this study was to investigate and quantify two biomarkers for radiation exposure (dicentrics and gamma-H2AX foci) in human lymphocytes after CT scans in the presence of an iodinated contrast agent. Blood samples from a healthy donor were exposed to CT scans in the absence or presence of iotrolan 300 at iodine concentrations of 5 or 50 mg ml(-1) blood. The samples were exposed to 0.025, 0.05, 0.1 and 1 Gy in a tissue equivalent body phantom. Chromosome aberration scoring and automated...     »
Journal title abbreviation:
Phys Med Biol
Year:
2009
Journal volume:
54
Journal issue:
20
Pages contribution:
6029-39
Language:
eng
Fulltext / DOI:
doi:10.1088/0031-9155/54/20/001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19779223
Print-ISSN:
0031-9155
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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