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Title:

Solid tumours arising from differently pre-oxygenated cells: comparable growth rates despite dissimilar tissue oxygenation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Mayer, A; Steimel, M; Wree, A; Kelleher, D; Vaupel, P
Abstract:
PURPOSE: The hypoxia-inducible factor (HIF)-dependent transcriptional response is often very pronounced in hypoxic microregions of solid malignant tumours, leading to secretion of pro-angiogenic factors and activation of a hypoxia-tolerant, glycolytic metabolism. Here, the influence of the microenvironment of tumour-initiating cells as a factor determining intertumoural variations in the relative contributions of both processes has been examined. MATERIAL AND METHODS: The oxygenation status was...     »
Journal title abbreviation:
Int J Radiat Biol
Year:
2009
Journal volume:
85
Journal issue:
11
Pages contribution:
981-8
Language:
eng
Fulltext / DOI:
doi:10.3109/09553000903232843
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19895275
Print-ISSN:
0955-3002
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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