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Title:

The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells.

Document type:
journal article
Author(s):
Elsner, L; Flügge, PF; Lozano, J; Muppala, V; Eiz-Vesper, B; Demiroglu, SY; Malzahn, D; Herrmann, T; Brunner, E; Bickeböller, H; Multhoff, G; Walter, L; Dressel, R
Abstract:
Abstract Although natural killer (NK) cells are often described as first line defense against infected or malignant cells which act without the need of prior activation, it is known now that the NK cell activity is tightly regulated by other cells and soluble factors. We show here that the stress-inducible heat shock protein (HSP) 70 activates human NK cells to kill target cells expressing MICA (major histocompatibility complex class I chain-related molecule A) in a NKG2D (natural killer group 2...     »
Journal title abbreviation:
J Cell Mol Med
Year:
2009
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19210576
Print-ISSN:
1582-1838
TUM Institution:
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie
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