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Titel:

The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells.

Dokumenttyp:
journal article
Autor(en):
Elsner, L; Flügge, PF; Lozano, J; Muppala, V; Eiz-Vesper, B; Demiroglu, SY; Malzahn, D; Herrmann, T; Brunner, E; Bickeböller, H; Multhoff, G; Walter, L; Dressel, R
Abstract:
Abstract Although natural killer (NK) cells are often described as first line defense against infected or malignant cells which act without the need of prior activation, it is known now that the NK cell activity is tightly regulated by other cells and soluble factors. We show here that the stress-inducible heat shock protein (HSP) 70 activates human NK cells to kill target cells expressing MICA (major histocompatibility complex class I chain-related molecule A) in a NKG2D (natural killer group 2...     »
Zeitschriftentitel:
J Cell Mol Med
Jahr:
2009
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19210576
Print-ISSN:
1582-1838
TUM Einrichtung:
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie
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