Benutzer: Gast  Login
Titel:

Prevention of interferon-stimulated gene expression using microRNA-designed hairpins.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Bauer, M; Kinkl, N; Meixner, A; Kremmer, E; Riemenschneider, M; Förstl, H; Gasser, T; Ueffing, M
Abstract:
RNA interference allows selective gene silencing, and is widely used for functional analysis of individual genes in vertebrate cells and represents an attractive therapeutic option for treating central nervous system diseases. However, growing evidence exists that the expression of short hairpin RNAs (shRNAs) can trigger cellular immune response resulting in unspecific cellular phenotypes and severe side effects. We found that lentiviral vector (LV)-mediated expression of shRNAs in primary corti...     »
Zeitschriftentitel:
Gene Ther
Jahr:
2009
Band / Volume:
16
Heft / Issue:
1
Seitenangaben Beitrag:
142-7
Sprache:
eng
Volltext / DOI:
doi:10.1038/gt.2008.123
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18701917
Print-ISSN:
0969-7128
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
 BibTeX