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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Higuchi, T; Anton, M; Saraste, A; Dumler, K; Pelisek, J; Nekolla, SG; Bengel, FM; Schwaiger, M
Title:
Reporter gene PET for monitoring survival of transplanted endothelial progenitor cells in the rat heart after pretreatment with VEGF and atorvastatin.
Abstract:
It has been suggested that vascular endothelial growth factor (VEGF) and statins enhance the survival, proliferation, and function of endothelial progenitor cells (EPCs). We investigated whether reporter gene PET can be used to detect the effects of atorvastatin and VEGF on survival of EPCs after transplantation in the rat heart. METHODS: Healthy nude rats received an intramyocardial injection of 4 million human EPCs retrovirally transduced with the sodium/iodide symporter gene for reporter gene...     »
Journal title abbreviation:
J Nucl Med
Year:
2009
Journal volume:
50
Journal issue:
11
Pages contribution:
1881-6
Language:
eng
Fulltext / DOI:
doi:10.2967/jnumed.109.067801
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19837770
Print-ISSN:
0161-5505
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Nuklearmedizin
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