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Title:

Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Vogler, M; Walczak, H; Stadel, D; Haas, TL; Genze, F; Jovanovic, M; Gschwend, JE; Simmet, T; Debatin, KM; Fulda, S
Abstract:
Resistance to apoptosis is a hallmark of pancreatic cancer, a leading cause of cancer deaths. Therefore, novel strategies are required to target apoptosis resistance. Here, we report that the combination of X-linked inhibitor of apoptosis (XIAP) inhibition and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an effective approach to trigger apoptosis despite Bcl-2 overexpression and to suppress pancreatic cancer growth in vitro and in vivo. Knockdown of XIAP by RNA interference...     »
Journal title abbreviation:
Cancer Res
Year:
2008
Journal volume:
68
Journal issue:
19
Pages contribution:
7956-65
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-08-1296
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18829553
Print-ISSN:
0008-5472
TUM Institution:
Urologische Klinik und Poliklinik
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