Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

Oxidative stress regulates expression of VEGFR1 in myeloid cells: link to tumor-induced immune suppression in renal cell carcinoma.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Kusmartsev, S; Eruslanov, E; Kubler, H; Tseng, T; Sakai, Y; Su, Z; Kaliberov, S; Heiser, A; Rosser, C; Dahm, P; Siemann, D; Vieweg, J
Abstract:
Metastatic renal cell carcinoma (RCC) associates with overproduction of vascular endothelial growth factor (VEGF) due to the mutation/inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. Herein we demonstrate that implantation of human RCC tumor cells into athymic nude mice promotes the appearance of VEGF receptor 1 (VEGFR1)/CD11b double-positive myeloid cells in peripheral blood. Avastin-mediated VEGF neutralization was capable of significantly reducing the numbers of circulating...     »
Zeitschriftentitel:
J Immunol
Jahr:
2008
Band / Volume:
181
Heft / Issue:
1
Seitenangaben Beitrag:
346-53
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18566400
Print-ISSN:
0022-1767
TUM Einrichtung:
Urologische Klinik und Poliklinik
 BibTeX