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Title:

EMAP-II downregulation contributes to the beneficial effects of rapamycin after vascular injury.

Document type:
Journal Article; Article
Author(s):
Nührenberg, TG; Langwieser, N; Schwarz, JB; Hou, Y; Frank, P; Sorge, F; Matschurat, S; Seidl, S; Kastrati, A; Schömig, A; Clauss, MA; Zohlnhofer, D
Abstract:
AIMS: Neointima formation after vascular injury is strongly associated with inflammation. Rapamycin inhibits human neointima formation and reduces expression of the proinflammatory cytokine endothelial-monocyte activating peptide II (EMAP-II) in vitro. Here we investigated the interplay between EMAP-II and rapamycin after vascular injury in vivo. METHODS AND RESULTS: In a mouse model of vascular injury, mice were either not treated, given everolimus, a rapamycin derivate, or subjected to simulta...     »
Journal title abbreviation:
Cardiovasc Res
Year:
2008
Journal volume:
77
Journal issue:
3
Pages contribution:
580-9
Language:
eng
Fulltext / DOI:
doi:10.1093/cvr/cvm076
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18029408
Print-ISSN:
0008-6363
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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