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Title:

Modulation of tissue factor and tissue factor pathway inhibitor-1 by neutrophil proteases.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Steppich, BA; Seitz, I; Busch, G; Stein, A; Ott, I
Abstract:
During systemic inflammation, neutrophil activation is accompanied by endothelial cell damage and hypercoagulability. Activated neutrophils release serine proteases that participate in tissue injury. We sought to investigate the effects of neutrophil proteases on proinflammatory and procoagulant changes in endothelial cells. The effects of elastase (HNE), cathepsin G (CG), and proteinase 3 (PR3) on expression of tissue factor (TF) and tissue factor pathway inhibitor-1 (TFPI) were examined in hum...     »
Journal title abbreviation:
Thromb Haemost
Year:
2008
Journal volume:
100
Journal issue:
6
Pages contribution:
1068-75
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19132232
Print-ISSN:
0340-6245
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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