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Title:

Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo.

Document type:
Journal Article; Article
Author(s):
Schulz, C; Penz, S; Hoffmann, C; Langer, H; Gillitzer, A; Schneider, S; Brandl, R; Seidl, S; Massberg, S; Pichler, B; Kremmer, E; Stellos, K; Schonberger, T; Siess, W; Gawaz, M
Abstract:
Platelet adhesion to the atherosclerotic vascular wall induces thrombosis and boosters vascular inflammation and atheroprogression. In the present study we studied the binding of the platelet collagen receptor glycoprotein (GP) VI to human atherosclerotic plaques (AP) and the role of GPVI-mediated platelet adhesion for atheroprogression. Soluble GPVI-Fc fusion protein bound to immobilized collagen type I, collagen type III, and predominantly to the core region of human carotid atheromatous plaqu...     »
Journal title abbreviation:
Basic Res Cardiol
Year:
2008
Journal volume:
103
Journal issue:
4
Pages contribution:
356-67
Language:
eng
Fulltext / DOI:
doi:10.1007/s00395-008-0722-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18431526
Print-ISSN:
0300-8428
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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