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Title:

Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hoffmann, TK; Sonkoly, E; Hauser, U; van Lierop, A; Whiteside, TL; Klussmann, JP; Hafner, D; Schüler, P; Friebe-Hoffmann, U; Scheckenbach, K; Erjala, K; Grénman, R; Schipper, J; Bier, H; Balz, V
Abstract:
Chemotherapy and/or radiotherapy are established measures in treatment protocols of head and neck squamous cell carcinoma (HNSCC). However, we still lack reliable predictive markers for the response to radio- and chemotherapy. The p53 pathway is involved in stress response and thus might influence chemo-/radiosensitivity. Using 29 HNSCC cell lines previously characterized for p53 mutations, we simultaneously analyzed several key players in the p53 pathway by RT-PCR, transcript sequencing and imm...     »
Journal title abbreviation:
Oral Oncol
Year:
2008
Journal volume:
44
Journal issue:
12
Pages contribution:
1100-9
Language:
eng
Fulltext / DOI:
doi:10.1016/j.oraloncology.2008.02.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18487078
Print-ISSN:
1368-8375
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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