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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Demmer, O; Dijkgraaf, I; Schottelius, M; Wester, HJ; Kessler, H
Titel:
Introduction of functional groups into peptides via N-alkylation.
Abstract:
An optimized protocol for the mild and selective Fukuyama-Mitsunobu reaction was used for mono- and di- N-alkylation on solid support. Thereby, nonfunctionalized aliphatic and aromatic residues are quickly introduced into transiently protected, primary amines of a linear peptide. N-Alkylation can also be used to implement alkyl chains carrying (protected) functionalities suited for subsequent modification. Applicability of this method is demonstrated by various N-alkylated analogues of a cyclic...     »
Zeitschriftentitel:
Org Lett
Jahr:
2008
Band / Volume:
10
Heft / Issue:
10
Seitenangaben Beitrag:
2015-8
Sprache:
eng
Volltext / DOI:
doi:10.1021/ol800654n
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18407647
Print-ISSN:
1523-7060
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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