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Title:

Paclitaxel in the neoadjuvant treatment for adeno carcinoma of the distal esophagus (AEG I). A comparison of two phase II trials with long-term follow-up.

Document type:
Journal Article; Article
Author(s):
Bader, FG; Lordick, F; Fink, U; Becker, K; Höfler, H; Busch, R; Siewert, JR; Ott, K
Abstract:
INTRODUCTION: We report a comparative analysis of 2 sequential, prospective phase II trials on the efficacy of platinum/leucovorin/5-fluorouracil (PLF) +/- paclitaxel (T-PLF) in the neoadjuvant treatment of adenocarcinoma of the esophagus (AEG I). PATIENTS AND METHODS: Inclusion criteria were histologically proven, locally advanced AEG I stage uT3/4 anyN cM0/M1a. 67 patients were treated with either PLF (n = 32) or T-PLF (n = 35). Paclitaxel (80 mg/m(2)) was added to PLF on days 1, 15, and 29. P...     »
Journal title abbreviation:
Onkologie
Year:
2008
Journal volume:
31
Journal issue:
7
Pages contribution:
366-72
Language:
eng
Fulltext / DOI:
doi:10.1159/000135515
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18596383
Print-ISSN:
0378-584X
TUM Institution:
Chirurgische Klinik und Poliklinik; III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie
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