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Title:

Histopathological response after preoperative radiochemotherapy in rectal carcinoma is associated with improved overall survival.

Document type:
Journal Article; Article
Author(s):
Rosenberg, R; Nekarda, H; Zimmermann, F; Becker, K; Lordick, F; Höfler, H; Molls, M; Siewert, JR
Abstract:
BACKGROUND: Recent studies showed improved local control after preoperative radiochemotherapy (RCTX) in patients with locally advanced rectal carcinoma, but failed to demonstrate a survival benefit. Our aims were to determine outcome and impact of histopathological response after preoperative RCTX. METHODS: One hundred four patients with uT3 rectal carcinoma were treated with preoperative RCTX of 45 Gy and continuous 5-FU infusion between 1997 and 2001 (group I). Histopathological response was e...     »
Journal title abbreviation:
J Surg Oncol
Year:
2008
Journal volume:
97
Journal issue:
1
Pages contribution:
8-13
Language:
eng
Fulltext / DOI:
doi:10.1002/jso.20844
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18085619
Print-ISSN:
0022-4790
TUM Institution:
Chirurgische Klinik und Poliklinik; III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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